Article
Biomarkers of DNA damage in patients with end-stage renal disease: mitochondrial DNA mutation in hair follicles.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Mar 2001
Liu C S, Ko L Y, Lim P S, Kao S H, Wei Y H
Abstract excerpt
BACKGROUND: DNA damage was noted in patients with end-stage renal disease (ESRD). Mitochondrial DNA (mtDNA) mutations have been proposed as a genomic biomarker in the process of human ageing, degenerative diseases and carcinogenesis. METHODS: Polymerase chain reaction (PCR) techniques were applied to detect mtDNA deletions in hair follicles, an appendage of skin, from 162 patients with ESRD. RESULTS: The...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.