Article
The human perforin gene is a direct target of STAT4 activated by IL-12 in NK cells.
Biochemical and biophysical research communications - 11 Oct 2002
Yamamoto Koh, Shibata Fumi, Miyasaka Nobuyuki, Miura Osamu
Abstract excerpt
IL-12 activates STAT4 by inducing tyrosine phosphorylation, homo-dimerization, and nuclear translocation in NK cells and thereby stimulates proliferation and activation of these cells. The pore-forming protein perforin is a key effector protein for NK cell- and cytotoxic T lymphocyte-mediated cytolysis. Here we demonstrate that IL-12 induces the expression of the perforin gene in human NK cell line, NKL....
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