Article
Amino acid deletions are introduced into the V2 region of gp120 during independent pathogenic simian immunodeficiency virus/HIV chimeric virus (SHIV) infections of rhesus monkeys generating variants that are macrophage tropic.
Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 2002
Imamichi Hiromi, Igarashi Tatsuhiko, Imamichi Tomozumi, Donau Olivia K, Endo Yasuyuki, Nishimura Yoshiaki, Willey Ronald L, Suffredini Anthony F, Lane H Clifford, Martin Malcolm A
Abstract excerpt
Highly pathogenic simian immunodeficiency virus/HIV chimeric viruses (SHIVs) cause extremely rapid, irreversible, and systemic depletions of CD4(+) T lymphocytes in inoculated rhesus monkeys. In the absence of this T cell subset, virus production can be sustained for several months by tissue macrophage. During independent infections of seven animals with uncloned virus stocks, SHIV variants emerged bearing amino...
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