Article
Ionic and cellular basis for the predominance of the Brugada syndrome phenotype in males.
Circulation - 8 Oct 2002
Di Diego José M, Cordeiro Jonathan M, Goodrow Robert J, Fish Jeffrey M, Zygmunt Andrew C, Pérez Guillermo J, Scornik Fabiana S, Antzelevitch Charles
Abstract excerpt
BACKGROUND: The Brugada syndrome displays an autosomal dominant mode of transmission with low penetrance. Despite equal genetic transmission of the disease, the clinical phenotype is 8 to 10 times more prevalent in males than in females. The basis for this intriguing sex-related distinction is unknown. The present study tests the hypothesis that the disparity in expression of the Brugada phenotype is a result of...
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