Article
A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome.
Cardiovascular research - 1 Mar 2009
Calloe Kirstine, Cordeiro Jonathan M, Di Diego José M, Hansen Rie S, Grunnet Morten, Olesen Søren Peter, Antzelevitch Charles
Abstract excerpt
AIMS: Transient outward potassium current (I(to)) is thought to be central to the pathogenesis of the Brugada syndrome (BrS). However, an I((to)) activator has not been available with which to validate this hypothesis. Here, we provide a direct test of the hypothesis using a novel I(to) activator, NS5806. METHODS AND RESULTS: Isolated canine ventricular myocytes and coronary-perfused wedge preparations were used....
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