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Article

Genotype-phenotype correlation in tissue models of Brugada syndrome simulating patients with sodium and calcium channelopathies.

Heart rhythm - 1 Jun 2010

Morita Hiroshi, Zipes Douglas P, Morita Shiho T, Wu Jiashin

Abstract excerpt

BACKGROUND: Genetic defects in the sodium channel or in the calcium channel have been identified in patients with Brugada syndrome (BS). However, the differences in their genotype-phenotype correlations are still unclear. OBJECTIVE: We evaluated the phenotypic differences and therapeutic effects between the sodium channel and calcium channel abnormalities in in vitro models of BS. METHODS: We created two models...

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PMID: 20206324
DOI: 10.1016/j.hrthm.2010.01.039

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