Article
HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors.
Nature immunology - 1 Nov 2002
Migueles Stephen A, Laborico Alisha C, Shupert W Lesley, Sabbaghian M Shirin, Rabin Ronald, Hallahan Claire W, Van Baarle Debbie, Kostense Stefan, Miedema Frank, McLaughlin Mary, Ehler Linda, Metcalf Julia, Liu Shuying, Connors Mark
Abstract excerpt
It is unclear why immunological control of HIV replication is incomplete in most infected individuals. We examined here the CD8+ T cell response to HIV-infected CD4+ T cells in rare patients with immunological control of HIV. Although high frequencies of HIV-specific CD8+ T cells were present in nonprogressors and progressors, only those of nonprogressors maintained a high proliferative capacity. This...
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