Article
Parathyroid hormone receptor type 1/Indian hedgehog expression is preserved in the growth plate of human fetuses affected with fibroblast growth factor receptor type 3 activating mutations.
The American journal of pathology - 1 Oct 2002
Cormier Sarah, Delezoide Anne-Lise, Benoist-Lasselin Catherine, Legeai-Mallet Laurence, Bonaventure Jacky, Silve Caroline
Abstract excerpt
The fibroblast growth factor receptor type 3 (FGFR3) and Indian hedgehog (IHH)/parathyroid hormone (PTH)/PTH-related peptide receptor type 1 (PTHR1) systems are both essential regulators of endochondral ossification. Based on mouse models, activation of the FGFR3 system is suggested to regulate the IHH/PTHR1 pathway. To challenge this possible interaction in humans, we analyzed the femoral growth plates from...
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