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Article

Neurodegenerative disease: amyloid pores from pathogenic mutations.

Nature - 18 Jul 2002

Lashuel Hilal A, Hartley Dean, Petre Benjamin M, Walz Thomas, Lansbury Peter T

Abstract excerpt

Alzheimer's and Parkinson's diseases are associated with the formation in the brain of amyloid fibrils from beta-amyloid and alpha-synuclein proteins, respectively. It is likely that oligomeric fibrillization intermediates (protofibrils), rather than the fibrils themselves, are pathogenic, but the mechanism by which they cause neuronal death remains a mystery. We show here that mutant amyloid proteins associated...

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Identifiers

PMID: 12124613
DOI: 10.1038/418291a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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