Article
LNA-enhanced detection of single nucleotide polymorphisms in the apolipoprotein E.
Nucleic acids research - 1 Oct 2002
Jacobsen Nana, Bentzen Joan, Meldgaard Michael, Jakobsen Mogens Havsteen, Fenger Mogens, Kauppinen Sakari, Skouv Jan
Abstract excerpt
Genotyping of single nucleotide polymorphisms (SNPs) in large populations presents a great challenge, especially if the SNPs are embedded in GC-rich regions, such as the codon 112 SNP in the human apolipoprotein E (apoE). In the present study, we have used immobilized locked nucleic acid (LNA) capture probes combined with LNA-enhancer oligonucleotides to obtain efficient and specific interrogation of SNPs in the...
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