Insulin-like growth factor binding protein-3 generation as a measure of GH sensitivity.

doi:10.1210/jc.2002-020045

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Article

Insulin-like growth factor binding protein-3 generation as a measure of GH sensitivity.

The Journal of clinical endocrinology and metabolism - 1 Oct 2002

Buckway C K, Selva K A, Pratt K L, Tjoeng E, Guevara-Aguirre J, Rosenfeld R G

Abstract excerpt

A total of 198 subjects were randomized to either high-dose (0.05 mg/kg.d) or low-dose (0.025 mg/kg.d) GH for 7 d; the alternate dose was then received after a 2-wk washout period. Groups included in the study were: normal, GH-insensitive (GHI; homozygous for the E180 splice mutation); heterozygous GHI (carriers of the E180 splice mutation); GH-deficient; and idiopathic short stature. Serum IGF binding protein-3...

Topics

Adolescent
Adult
Body Height
Child
Drug Resistance
Female
Heterozygote
Human Growth Hormone
Humans
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kinetics

Male

Mutation

RNA Splicing

Receptors, Somatotropin

Sensitivity and Specificity

Source

Open in PubMed

Identifiers

PMID: 12364470
DOI: 10.1210/jc.2002-020045

Provenance

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