Article
Partial growth hormone insensitivity--idiopathic short stature is not always idiopathic.
Acta paediatrica (Oslo, Norway : 1992). Supplement - 1 Feb 1999
Saenger P
Abstract excerpt
Heterozygous growth hormone receptor (GHR) gene defects are not a common cause of idiopathic short stature. Although some of these GHR mutations may result in relative insensitivity to growth hormone (GH) in other studies, obligate heterozygotes did not present any clinical manifestations. Although patients with GH insensitivity and elevated GH binding protein (GHBP) levels have been described, it may be a...
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