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Article

A Clinical Trial of High-Dose Growth Hormone in a Patient With a Dominant-Negative Growth Hormone Receptor Mutation.

The Journal of clinical endocrinology and metabolism - 15 Oct 2024

Merchant Nadia, Houchin Lisa, Boucher Kimberly, Dauber Andrew

Abstract excerpt

CONTEXT: Rare patients with short stature and growth hormone (GH) resistance have dominant-negative variants in the GH receptor. We describe a patient with GH resistance due to elevated levels of GH binding protein and demonstrate the potential for a precision medicine intervention. OBJECTIVE: To determine whether high-dose GH can overcome GH resistance in this specific patient resulting in normal insulin-like...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38597155
DOI: 10.1210/clinem/dgae244
PMCID: PMC11479683

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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