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Article

Coilin methylation regulates nuclear body formation.

Developmental cell - 1 Sept 2002

Hebert Michael D, Shpargel Karl B, Ospina Jason K, Tucker Karen E, Matera A Gregory

Abstract excerpt

Cajal bodies (CBs) are nuclear suborganelles involved in biogenesis of small RNAs. Twin structures, called gems, contain high concentrations of the survival motor neurons (SMN) protein complex. CBs and gems often colocalize, and communication between these subdomains is mediated by coilin, the CB marker. Coilin contains symmetrical dimethylarginines that modulate its affinity for SMN, and, thus, localization of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12361597
DOI: 10.1016/s1534-5807(02)00222-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Coilin methylation regulates nuclear body formation.PMID 12361597Read ↗

Gemin proteins are required for efficient assembly of Sm-class ribonucleoproteinsSemantic proximity Read ↗

Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies.Semantic proximity Read ↗

Coilin is essential for Cajal body organization in Drosophila melanogaster.Semantic proximity Read ↗

<i>Gemin4</i> is an essential gene in mice, and its overexpression in human cells causes relocalization of the SMN complex to the nucleoplasmSemantic proximity Read ↗

Cajal bodies in neuronsSemantic proximity Read ↗

Nucleolar reorganization after cellular stress is orchestrated by SMN shuttling between nuclear compartmentsSemantic proximity Read ↗

The Spinal Muscular Atrophy Disease Gene Product, SmnSemantic proximity Read ↗

Self-association of coilin reveals a common theme in nuclear body localization.Semantic proximity Read ↗

The integrator complex is required for integrity of Cajal bodies.Semantic proximity Read ↗

Gemins modulate the expression and activity of the SMN complexSemantic proximity Read ↗

WRAP53 Is Essential for Cajal Body Formation and for Targeting the Survival of Motor Neuron Complex to Cajal BodiesSemantic proximity Read ↗

A point mutation in human coilin prevents Cajal body formation.Semantic proximity Read ↗

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