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Article

Searching for quantitative entropy-enthalpy compensation among protein variants.

Proteins - 15 Nov 2002

Beasley James R, Doyle Donald F, Chen Lixin, Cohen David S, Fine Bryan R, Pielak Gary J

Abstract excerpt

Entropy-enthalpy (SH) compensation occurs when a small change in DeltaG is caused by large, and nearly compensatory, changes in DeltaH and DeltaS. It is considered a ubiquitous property of reactions in water. Because water is intimately involved in protein stability, SH compensation among protein variants, if it exists, could lead to important knowledge about protein-water interactions. In light of recent...

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PMID: 12360529
DOI: 10.1002/prot.10189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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