Article
Association of two gene polymorphisms with osteoarthritis secondary to hip dysplasia.
Clinical orthopaedics and related research - 1 Oct 2002
Granchi Donatella, Stea Susanna, Sudanese Alessandra, Toni Aldo, Baldini Nicola, Giunti Armando
Abstract excerpt
Two adjacent genes on the 12q chromosome, the alpha 1 chain of Type II collagen, and the vitamin D receptor, have been considered potentially related to the pathophysiology of osteoarthritis. Two restriction fragment length polymorphisms were detected in 50 healthy donors and in 143 patients having a total hip replacement for idiopathic osteoarthritis or osteoarthritis secondary to developmental hip dysplasia....
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