Article
A common polymorphic allele of the human luteinizing hormone beta-subunit gene: additional mutations and differential function of the promoter sequence.
Human molecular genetics - 1 Oct 1999
Jiang M, Pakarinen P, Zhang F P, El-Hefnawy T, Koskimies P, Pettersson K, Huhtaniemi I
Abstract excerpt
A common genetic variant (V) of the human luteinizing hormone (LH) beta-subunit gene was recently discovered. The V-LH molecules have higher bioactivity in vitro, but shorter half-life in circulation, which apparently is related to the alterations of LH function observed in individuals homo- and heterozygous for the V-LHbeta allele. We have now studied whether additional mutations in the V-LHbeta promoter...
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