Disparate response of wild-type and variant forms of LH to GnRH stimulation in individuals heterozygous for the LHbeta variant allele.

doi:10.1093/humrep/16.2.230

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Article

Disparate response of wild-type and variant forms of LH to GnRH stimulation in individuals heterozygous for the LHbeta variant allele.

Human reproduction (Oxford, England) - 1 Feb 2001

Nilsson C H, Kaleva M, Virtanen H, Haavisto A M, Pettersson K, Huhtaniemi I T

Abstract excerpt

There is a common genetic variant of LH due to two amino acid changes in the LHbeta subunit, Trp(8)Arg and Ile(15)Thr. In order to compare the relative activities of wild type (wt-LH) and variant LHbeta (v-LHbeta) genes in LH production and secretion, we performed gonadotrophin-releasing hormone (GnRH) stimulation tests for healthy females (n = 7) and males (n = 10) heterozygous for the v-LHbeta allele. Blood...

Topics

Adolescent
Adult
Alleles
Animals
Biological Assay
Estradiol
Female
Genetic Variation
Gonadotropin-Releasing Hormone
Heterozygote
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leydig Cells

Luteinizing Hormone

Male

Mice

Sex Characteristics

Testosterone

Source

Open in PubMed

Identifiers

PMID: 11157812
DOI: 10.1093/humrep/16.2.230

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