Article
A common polymorphic allele of the LH beta-subunit gene is associated with higher exogenous FSH consumption during controlled ovarian stimulation for assisted reproductive technology.
Reproductive biology and endocrinology : RB&E - 1 Jun 2013
Alviggi Carlo, Pettersson Kim, Longobardi Salvatore, Andersen Claus Yding, Conforti Alessandro, De Rosa Pasquale, Clarizia Roberto, Strina Ida, Mollo Antonio, De Placido Giuseppe, Humaidan Peter
Abstract excerpt
BACKGROUND: V-betaLH is a common genetic variant of LH caused by two polymorphic base changes in the beta subunit gene, altering the amino acid sequence (Trp8Arg and Ile15Thr). In a previous-preliminary trial performed in women undergoing IVF, it was demonstrated that carriers of v-betaLH show sub-optimal ovarian response to a standard long GnRH-agonist down -regulation protocol when stimulated with pure...
Topics
- Adult
- Alleles
- Denmark
- Estrogens
- Female
- Follicle Stimulating Hormone
- Gene Frequency
- Gonadotropin-Releasing Hormone
- Humans
- Infertility, Female