Article
Molecular evolution of the Rab-escort-protein/guanine-nucleotide-dissociation-inhibitor superfamily.
Molecular biology of the cell - 1 Sept 2003
Alory Christelle, Balch William E
Abstract excerpt
Prenylation of Rab GTPases regulating vesicle traffic by Rab geranylgeranyltransferase (RabGGTase) requires a complex formed by the association of newly synthesized Rab proteins with Rab-escort-protein (REP), the choroideremia-gene-product that is mutated in disease, leading to loss of vision. After delivery to the membrane by the REP-Rab complex, subsequent recycling to the cytosol requires the REP-related...
Topics
- Alkyl and Aryl Transferases
- Escherichia coli
- Evolution, Molecular
- Guanine Nucleotide Dissociation Inhibitors
- Models, Structural
- Mutation
- Protein Binding
- Protein Prenylation
- Protein Structure, Tertiary
- Saccharomyces cerevisiae