Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Low levels of Ypt protein prenylation cause vesicle polarization defects and thermosensitive growth that can be suppressed by genes involved in cell wall maintenance.

Molecular microbiology - 1 Mar 2000

Bialek-Wyrzykowska U, Bauer B E, Wagner W, Kohlwein S D, Schweyen R J, Ragnini A

Abstract excerpt

The Rab/Ypt small G proteins are essential for intracellular vesicle trafficking in mammals and yeast. The vesicle-docking process requires that Ypt proteins are located in the vesicle membrane. C-terminal geranylgeranyl anchors mediate the membrane attachment of these proteins. The Rab escort protein (REP) is essential for the recognition of Rab/Ypt small G proteins by geranylgeranyltransferase II (GGTase II)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alkyl and Aryl Transferases
Share to Benzenesulfonates

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myosin Light Chains

Share to Protein Prenylation

Share to rab GTP-Binding Proteins

Share to Sorbitol

Share to Suppression, Genetic

Share to Vesicular Transport Proteins

Source

Identifiers

PMID: 10760132
DOI: 10.1046/j.1365-2958.2000.01782.x

Genes

MLC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low levels of Ypt protein prenylation cause vesicle polarization defects and thermosensitive growth that can be suppressed by genes involved in cell wall maintenance.PMID 10760132Read ↗

Ypt protein prenylation depends on the interplay among levels of Rab escort protein and geranylgeranyl diphosphate in yeast cells.Semantic proximity Read ↗

Mutation of the Rab6 homologue of Saccharomyces cerevisiae, YPT6, inhibits both early Golgi function and ribosome biosynthesis.Semantic proximity Read ↗

Expression of mammalian Rab Escort protein-1 and -2 in yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Biochemical and genetic evidence for the involvement of yeast Ypt6-GTPase in protein retrieval to different Golgi compartments.Semantic proximity Read ↗

Sec7p directs the transitions required for yeast Golgi biogenesis.Semantic proximity Read ↗

Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily.Semantic proximity Read ↗

Membrane metabolism mediated by Sec14 family members influences Arf GTPase activating protein activity for transport from the trans-Golgi.Semantic proximity Read ↗

Role of the Rab GTP-binding protein Ypt3 in the fission yeast exocytic pathway and its connection to calcineurin function.Semantic proximity Read ↗

Endocytic recycling in yeast is regulated by putative phospholipid translocases and the Ypt31p/32p-Rcy1p pathway.Semantic proximity Read ↗

Hydrolysis of GTP by Sec4 protein plays an important role in vesicular transport and is stimulated by a GTPase-activating protein in Saccharomyces cerevisiae.Semantic proximity Read ↗

Evidence for the intimate relationship between vesicle budding from the ER and the unfolded protein response.Semantic proximity Read ↗

Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.