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Article

An in ovo chicken model to study the systemic and localized teratogenic effects of valproic acid

25 Sept 2002

Abstract excerpt

BACKGROUND: The antiepileptic valproic acid (VPA) is a teratogen whose embryopathic mechanism(s) remain uncertain. Elucidating potential cellular and molecular effects of VPA is complicated by systemic application paradigms. We developed an in ovo model to reproduce the teratogenic effects of VPA and a localized VPA application procedure to determine whether VPA can selectively effect abnormal development in one...

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PMID: 12353211
DOI: 10.1002/tera.10093

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