Article
Tacrine-induced liver damage: an analysis of 19 candidate genes.
Pharmacogenetics and genomics - 1 Dec 2007
Alfirevic Ana, Mills Tracy, Carr Daniel, Barratt Bryan J, Jawaid Ansar, Sherwood James, Smith John C, Tugwood Jonathan, Hartkoorn Ruben, Owen Andrew, Park Kevin B, Pirmohamed Munir
Abstract excerpt
OBJECTIVES: Tacrine, the first acetylcholinesterase inhibitor used in the treatment of Alzheimer's disease, is associated with transaminase elevation in up to 50% of patients. The mechanism of tacrine-induced liver damage is not fully understood, but earlier studies have suggested that genetic factors may play a role. Our aim was to investigate whether single-nucleotide polymorphisms (SNPs) in 19 candidate genes...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.