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Article

Metapopulation dynamics and spatial heterogeneity in cancer.

Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 2002

González-García Isabel, Solé Ricard V, Costa José

Abstract excerpt

With the advent of drugs targeting specific molecular defects in cancerous cells [Gorre, M. E., et al. (2001) Science 293, 876-880], it is important to understand the degree of genetic heterogeneity present in tumor cell populations and the rules that govern microdiversity in human cancer. Here, we first show that populations with different genotypes in genes influencing cell growth and programmed cell death...

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Identifiers

PMID: 12351679
DOI: 10.1073/pnas.202139299
PMCID: PMC130590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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