Article
Transplantation of wild-type spermatogonia leads to complete spermatogenesis in testes of cyclic 3',5'-adenosine monophosphate response element modulator-deficient mice.
Biology of reproduction - 1 Oct 2002
Wistuba Joachim, Schlatt Stefan, Cantauw Carsten, von Schönfeldt Viktoria, Nieschlag Eberhard, Behr Rüdiger
Abstract excerpt
The cAMP response element modulator (CREM) gene encodes transcription factors that are highly expressed in spermatids. A deficiency of the CREM gene leads to male infertility in mice due to round spermatid maturation arrest. However, CREM is also expressed in testicular Sertoli cells. We investigated whether CREM deficiency affects the germ line alone or whether the testicular environment is also dependent on...
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