Article
Abnormal sperm in mice with targeted deletion of the act (activator of cAMP-responsive element modulator in testis) gene.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 2004
Kotaja Noora, De Cesare Dario, Macho Betina, Monaco Lucia, Brancorsini Stefano, Goossens Ellen, Tournaye Herman, Gansmuller Anne, Sassone-Corsi Paolo
Abstract excerpt
ACT [activator of cAMP-responsive element modulator (CREM) in testis] is a LIM-only protein that interacts with transcription factor CREM in postmeiotic male germ cells and enhances CREM-dependent transcription. CREM regulates many crucial genes required for spermatid maturation, and targeted mutation of the Crem gene in the mouse germ-line blocks spermatogenesis. Here we report the phenotype of mice in which...
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