cAMP response element modulator (CREM): an essential factor for spermatogenesis in primates?

doi:10.1046/j.1365-2605.2001.00277.x

Article

cAMP response element modulator (CREM): an essential factor for spermatogenesis in primates?

1 Jun 2001

Abstract excerpt

CREM is a cAMP-related transcription factor and alternate promotor usage and splicing generate repressor and activator transcripts of CREM within the testis. CREM activators are highly expressed in post-meiotic haploid germ cells and are essential for spermatid maturation in the mouse model as revealed by gene-targeting studies. Analysis of testicular CREM expression in rodent and monkey species, and in men...

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