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Article

The low gonadotropin-independent constitutive production of testicular testosterone is sufficient to maintain spermatogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 2003

Zhang Fu-Ping, Pakarainen Tomi, Poutanen Matti, Toppari Jorma, Huhtaniemi Ilpo

Abstract excerpt

Spermatogenesis is thought to critically depend on the high intratesticular testosterone (T) levels induced by gonadotropic hormones. Strategies for hormonal male contraception are based on disruption of this regulatory mechanism through blockage of gonadotropin secretion. Although exogenous T or T plus progestin treatments efficiently block gonadotropin secretion and suppress testicular T production, only...

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Identifiers

PMID: 14585929
DOI: 10.1073/pnas.2232815100
PMCID: PMC263875

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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