Article
Codon 45 of the beta-catenin gene, a specific mutational target site of Wilms' tumor.
International journal of molecular medicine - 1 Oct 2002
Kusafuka Takeshi, Miao Jiangyong, Kuroda Seika, Udatsu Yoko, Yoneda Akihiro
Abstract excerpt
Wilms' tumor (WT) is the most common childhood renal malignancy. Although several genetic loci such as the WT1 gene have been known to relate to the biology of WT, the cause of the tumor is complex and the implicated molecular pathways are largely unknown. The beta-catenin gene encodes a protein playing an important role in the Wnt signaling pathway, and its mutations that abrogate specific serine/threonine...
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