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Article

A Gap-Junction Mutation Reveals That Outer Hair Cell Extracellular Receptor Potentials Drive High-Frequency Cochlear Amplification.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 Oct 2022

Levic Snezana, Lukashkina Victoria A, Simões Patricio, Lukashkin Andrei N, Russell Ian J

Abstract excerpt

Cochlear amplification enables the enormous dynamic range of hearing through amplifying cochlear responses to low- to moderate-level sounds and compressing them to loud sounds. Amplification is attributed to voltage-dependent electromotility of mechanosensory outer hair cells (OHCs) driven by changing voltages developed across their cell membranes. At low frequencies, these voltage changes are dominated by...

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Identifiers

PMID: 36261265
DOI: 10.1523/JNEUROSCI.2241-21.2022
PMCID: PMC9617611

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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