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Article

Activity-dependent regulation of prestin expression in mouse outer hair cells.

Journal of neurophysiology - 1 Jun 2015

Song Yohan, Xia Anping, Lee Hee Yoon, Wang Rosalie, Ricci Anthony J, Oghalai John S

Abstract excerpt

Prestin is a membrane protein necessary for outer hair cell (OHC) electromotility and normal hearing. Its regulatory mechanisms are unknown. Several mouse models of hearing loss demonstrate increased prestin, inspiring us to investigate how hearing loss might feedback onto OHCs. To test whether centrally mediated feedback regulates prestin, we developed a novel model of inner hair cell loss. Injection of...

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Identifiers

PMID: 25810486
DOI: 10.1152/jn.00869.2014
PMCID: PMC4461885

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