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Article

Early opening of sarcolemmal ATP-sensitive potassium channels is not a key step in PKC-mediated cardioprotection.

Journal of molecular and cellular cardiology - 1 Feb 2015

Brennan Sean, Jackson Robert, Patel Manish, Sims Mark W, Hudman Diane, Norman Robert I, Lodwick David, Rainbow Richard D

Abstract excerpt

ATP-sensitive potassium (KATP) channels are abundantly expressed in the myocardium. Although a definitive role for the channel remains elusive they have been implicated in the phenomenon of cardioprotection, but the precise mechanism is unclear. We set out to test the hypothesis that the channel protects by opening early during ischemia to shorten action potential duration and reduce electrical excitability thus...

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Identifiers

PMID: 25450614
DOI: 10.1016/j.yjmcc.2014.10.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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