Article
Prognostic value of KIT mutation type, mitotic activity, and histologic subtype in gastrointestinal stromal tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 15 Sept 2002
Singer Samuel, Rubin Brian P, Lux Marcia L, Chen Chang-Jie, Demetri George D, Fletcher Christopher D M, Fletcher Jonathan A
Abstract excerpt
PURPOSE: Previous studies have reported clinical correlates for KIT mutations in GISTs, but in most of those studies the KIT mutations were found in less than 50% of the GISTs. The aim of this study was to evaluate the prognostic relevance for KIT mutations in a series of GISTs in which the mutations were evaluated intensively by genomic and cDNA sequencing. PATIENTS AND METHODS: A comprehensive clinical and...
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