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Article

KIT and PDGFRA mutations and the risk of GI stromal tumor recurrence.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Feb 2015

Joensuu Heikki, Rutkowski Piotr, Nishida Toshirou, Steigen Sonja E, Brabec Peter, Plank Lukas, Nilsson Bengt, Braconi Chiara, Bordoni Andrea, Magnusson Magnus K, Sufliarsky Jozef, Federico Massimo, Jonasson Jon G, Hostein Isabelle, Bringuier Pierre-Paul, Emile Jean-Francois

Abstract excerpt

PURPOSE: Mutated KIT and platelet-derived growth factor alpha gene (PDGFRA) drive GI stromal tumor (GIST) oncogenesis, but the clinical significance of their single mutations is known incompletely. PATIENTS AND METHODS: We identified 11 population-based series of patients with GIST through a literature search and pooled individual data from 3,067 patients treated with macroscopically complete tumor excision....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrointestinal Neoplasms

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Share to Neoplasm Recurrence, Local

Share to Proto-Oncogene Proteins c-kit

Share to Receptor, Platelet-Derived Growth Factor alpha

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Source

Identifiers

PMID: 25605837
DOI: 10.1200/JCO.2014.57.4970

Genes

KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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