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Article

Molecular subtypes of gastrointestinal stromal tumors and their prognostic and therapeutic implications.

Future oncology (London, England) - 1 Jan 2017

Szucs Zoltan, Thway Khin, Fisher Cyril, Bulusu Ramesh, Constantinidou Anastasia, Benson Charlotte, van der Graaf Winette Ta, Jones Robin L

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) are composed of various molecular subtypes, with differing prognostic and predictive relevance. Previously, tumors lacking mutations in the KIT and PDGFRA genes have been designated as 'wild-type' GISTs; however, they represent a heterogeneous group currently undergoing further subclassification. Primary and secondary resistance to imatinib poses a significant clinical...

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Source

Identifiers

PMID: 27600498
DOI: 10.2217/fon-2016-0192

Genes

KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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