Article
Glyceraldehyde-3-phosphate dehydrogenase aggregate formation participates in oxidative stress-induced cell death.
The Journal of biological chemistry - 4 Dec 2009
Nakajima Hidemitsu, Amano Wataru, Kubo Takeya, Fukuhara Ayano, Ihara Hideshi, Azuma Yasu-Taka, Tajima Hisao, Inui Takashi, Sawa Akira, Takeuchi Tadayoshi
Abstract excerpt
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)(2) is a classic glycolytic enzyme that also mediates cell death by its nuclear translocation under oxidative stress. Meanwhile, we previously presented that oxidative stress induced disulfide-bonded GAPDH aggregation in vitro. Here, we propose that GAPDH aggregate formation might participate in oxidative stress-induced cell death both in vitro and in vivo. We show...
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