Article
Expression and characterization of a mutant recombinant blood coagulation factor VIII (rFVIII (m)).
Experimental & molecular medicine - 31 Jul 2002
Oh Sang Hwan, Cho Sun Young, Jin Hyun Sun, Jeong Deuk-Lim, Jung Sung-Gil, Oh Keun Hee
Abstract excerpt
In an earlier study, a site directed mutant rFVIII (rFVIII(m), Arg(336) --> Gln(336)) expressed in baculovirus-insect cell (Sf9) system was found to sustain high level activity during incubation at 37 degrees celsius for 24 h while the cofactor activity of normal plasma was declined steadily. In this study, a mutant B-domain deleted rFVIII(m), Arg(336) --> Gln(336) expressed in baculovirus-insect cell (Sf9)...
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