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Recombinant clotting factors

1 Jan 2008

Abstract excerpt

The recombinant era for haemophilia began in the early 1980s with the cloning and subsequent expression of functional proteins for both factors VIII and IX. Efficient production of recombinant clotting factors in mammalian cell culture systems required overcoming significant challenges due to the complex post-translational modifications that were integral to their pro-coagulant function. The quick development and...

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PMID: 18449413
DOI: 10.1160/th07-10-0593

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