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Article

Msc1 links dynamic Swi6/HP1 binding to cell fate determination.

Proceedings of the National Academy of Sciences of the United States of America - 27 Jan 2009

Lawrence Richard J, Volpe Thomas A

Abstract excerpt

Eukaryotic genomes can be organized into distinct domains of heterochromatin or euchromatin. In the fission yeast Schizosaccharomyces pombe, assembly of heterochromatin at the silent mating-type region is critical for cell fate determination in the form of mating-type switching. Here, we report that the ubiquitin ligase, Msc1, is a critical factor required for proper cell fate determination in S. pombe. In the...

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Source

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Identifiers

PMID: 19164572
DOI: 10.1073/pnas.0811161106
PMCID: PMC2633577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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