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Article

nup1 mutants exhibit pleiotropic defects in nuclear pore complex function.

The Journal of cell biology - 1 Oct 1994

Bogerd A M, Hoffman J A, Amberg D C, Fink G R, Davis L I

Abstract excerpt

The NUP1 gene of Saccharomyces cerevisiae encodes one member of a family of nuclear pore complex proteins (nucleoporins) conserved from yeast to vertebrates. We have used mutational analysis to investigate the function of Nup1p. Deletion of either the amino- or carboxy-terminal domain confers a lethal phenotype, but partial truncations at either end affect growth to varying extents. Amino-terminal truncation...

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Identifiers

PMID: 7929578
DOI: 10.1083/jcb.127.2.319
PMCID: PMC2120204

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