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SRD5A polymorphisms and biochemical failure after radical prostatectomy.

European urology - 1 Dec 2011

Audet-Walsh Etienne, Bellemare Judith, Nadeau Geneviève, Lacombe Louis, Fradet Yves, Fradet Vincent, Huang Shu-Pin, Bao Bo-Ying, Douville Pierre, Girard Hugo, Guillemette Chantal, Lévesque Eric

Abstract excerpt

BACKGROUND: The relationship between inherited germ-line variations in the 5α-reductase pathways of androgen biosynthesis and the risk of biochemical recurrence (BCR) after radical prostatectomy (RP) remains an unexplored area. OBJECTIVE: To determine the link between germ-line variations in the steroid-5α-reductase, α-polypeptide 1 (SRD5A1) and steroid-5α-reductase, α-polypeptide 2 (SRD5A2) genes and BCR....

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PMID: 21715084
DOI: 10.1016/j.eururo.2011.06.020

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