Article
High fidelity of homologous retroviral recombination in cell culture.
Archives of virology - 1 Sept 2002
Bircher L A, Rigano J C, Ponferrada V G, Wooley D P
Abstract excerpt
Genetic variation continues to be a major obstacle in the development of therapies and vaccines against retroviral infections and contributes extensively to viral pathogenesis and persistence. Recombination is one mechanism that increases retroviral variation by shuffling mutations from different genomes. Recent studies suggest that recombination not only shuffles the mutations but also generates them at high...
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