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Article

Gln277 and Phe554 residues are involved in thermal inactivation of protective antigen of Bacillus anthracis.

Biochemical and biophysical research communications - 6 Sept 2002

Singh Samer, Ahuja Nidhi, Chauhan Vibha, Rajasekaran E, Mohsin Waheed Syed, Bhat Rajiv, Bhatnagar Rakesh

Abstract excerpt

Protective antigen (PA) is the main component of all the vaccines against anthrax. The currently available vaccines have traces of other proteins that contribute to its reactogenicity. Thus, purified PA is recommended for human vaccination. PA loses its biological activity within 48h at 37 degrees C and its thermolability has been a cause of concern as accidental exposure to higher temperatures during...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12207879
DOI: 10.1016/s0006-291x(02)02049-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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