Article
Influence of a glutamate carboxypeptidase II (GCPII) polymorphism (1561C-->T) on plasma homocysteine, folate and vitamin B(12) levels and its relationship to cardiovascular disease risk.
Atherosclerosis - 1 Oct 2002
Lievers Karin J A, Kluijtmans Leo A J, Boers Godfried H J, Verhoef Petra, den Heijer Martin, Trijbels Frans J M, Blom Henk J
Abstract excerpt
Elevated levels of total homocysteine and low folate in blood are independent and graded risk factors for arterial occlusive disease. An impairment of folate distribution can be an important cause of hyperhomocysteinemia. Glutamate carboxypeptidase II (GCPII) regulates the absorption of dietary folates. In the present study, we examined the relationship of a 1561C-->T variant in the GCPII gene with fasting,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.