Article
Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia.
Human molecular genetics - 22 Nov 2000
Devlin A M, Ling E H, Peerson J M, Fernando S, Clarke R, Smith A D, Halsted C H
Abstract excerpt
Low blood folate levels result in hyperhomocysteinemia, which has been associated with increased risk for cardiovascular disease, neural tube defects and cognitive deficits. Intake of dietary folates is the chief determinant of blood folate levels. Molecular defects in the intestinal absorption of dietary folates that precipitate low blood folate levels and hyperhomocysteinemia have not been investigated...
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