Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of glutamate carboxypeptidase II and reduced folate carrier polymorphisms on folate and total homocysteine concentrations in dialysis patients.

Journal of the American Society of Nephrology : JASN - 1 May 2003

Födinger Manuela, Dierkes Jutta, Skoupy Sonja, Röhrer Claudia, Hagen Wolfgang, Puttinger Heidi, Hauser Anna-Christine, Vychytil Andreas, Sunder-Plassmann Gere

Abstract excerpt

This study was designed to examine the effect of two single nucleotide polymorphisms in the reduced folate carrier 1 (RFC1 80G>A) and the glutamate carboxypeptidase 2 (GCP2 1561C>T) gene on total homocysteine (tHcy) plasma level and folate status in 120 chronic dialysis patients. Red blood cell folate concentration was higher in patients with the GCP2 CT or TT genotype (ANOVA, P = 0.04). Among patient groups with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Surface
Share to Carboxypeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Erythrocytes

Share to Folic Acid

Share to Homocysteine

Share to Kidney Failure, Chronic

Share to Receptors, Cell Surface

Share to Renal Dialysis

Source

Identifiers

PMID: 12707400
DOI: 10.1097/01.asn.0000064949.67401.d3

Genes

RFC1
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of glutamate carboxypeptidase II and reduced folate carrier polymorphisms on folate and total homocysteine concentrations in dialysis patients.PMID 12707400Read ↗

Effects of the glutamate carboxypeptidase II (GCP2 1561C>T) and reduced folate carrier (RFC1 80G>A) allelic variants on folate and total homocysteine levels in kidney transplant patients.Semantic proximity Read ↗

Association of two MTHFR polymorphisms with total homocysteine plasma levels in dialysis patients.Semantic proximity Read ↗

Relations of glutamate carboxypeptidase II (GCPII) polymorphisms to folate and homocysteine concentrations and to scores of cognition, anxiety, and depression in a homogeneous Norwegian population: the Hordaland Homocysteine Study.Semantic proximity Read ↗

Influence of a glutamate carboxypeptidase II (GCPII) polymorphism (1561C-->T) on plasma homocysteine, folate and vitamin B(12) levels and its relationship to cardiovascular disease risk.Semantic proximity Read ↗

Hyperhomocysteinaemia, folate and vitamin B12 in unsupplemented haemodialysis patients: effect of oral therapy with folic acid and vitamin B12.Semantic proximity Read ↗

Hyperhomocysteinemia is related to residual glomerular filtration and folate, but not to methylenetetrahydrofolate-reductase and methionine synthase polymorphisms, in supplemented end-stage renal disease patients undergoing hemodialysis.Semantic proximity Read ↗

The glutamate carboxypeptidase gene II (C>T) polymorphism does not affect folate status in the Framingham Offspring cohort.Semantic proximity Read ↗

Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population.Semantic proximity Read ↗

Vitamin B12 decreases, but does not normalize, homocysteine and methylmalonic acid in end-stage renal disease: a link with glycine metabolism and possible explanation of hyperhomocysteinemia in end-stage renal disease.Semantic proximity Read ↗

Increased prevalence of combined MTR and MTHFR genotypes among individuals with severely elevated total homocysteine plasma levels.Semantic proximity Read ↗

Homocysteine, folate, vitamin B12 levels, and C677T MTHFR mutation in children with renal failure.Semantic proximity Read ↗

The folate hydrolase 1561C>T polymorphism is associated with depressive symptoms in Puerto Rican adults.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.