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Article

Paradoxical role of C1561T glutamate carboxypeptidase II (GCPII) genetic polymorphism in altering disease susceptibility.

Gene - 15 Apr 2012

Divyya Shree, Naushad Shaik Mohammad, Addlagatta Anthony, Murthy P V L N, Reddy Ch Ram, Digumarti Raghunadha Rao, Gottumukkala Suryanarayana Raju, Kumar Ajit, Rammurti S, Kutala Vijay Kumar

Abstract excerpt

Glutamate carboxypeptidase II (GCPII) is predominantly expressed in brain, intestinal mucosa and prostate cancer in the form of three splice variants i.e. N-acetylated-α-linked acidic dipeptidase (NAALADase), folyl poly-γ-glutamate carboxypeptidase (FGCP) and prostate specific membrane antigen (PSMA) respectively. Its inhibition was found to confer protection against certain neurological disorders and cancer....

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PMID: 22310383
DOI: 10.1016/j.gene.2012.01.055

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