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Analysis of breast cancer susceptibility genes BRCA1 and BRCA2 in Thai familial and isolated early-onset breast and ovarian cancer.

Human mutation - 1 Sept 2002

Patmasiriwat Pimpicha, Bhothisuwan Kris, Sinilnikova Olga M, Chopin Sandrine, Methakijvaroon Suthida, Badzioch Michael, Padungsutt Puchong, Vattanaviboon Phantip, Vattanasapt Vanchai, Szabo Csilla, Saunders Grady F, Goldgar David, Lenoir Gilbert M

Abstract excerpt

Here we report the study on BRCA1 and BRCA2 mutations in 12 Thai breast and/or ovarian cancer families and 6 early-onset breast or breast/ovarian cancer cases without a family history of cancer. Five distinct rare alterations were identified in each gene: four introducing premature stop codons, one in-frame deletion, two missense changes, two intronic alterations and one silent rare variant. The BRCA1 or BRCA2...

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Identifiers

PMID: 12203997
DOI: 10.1002/humu.9049

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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