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BRCA1 and BRCA2 mutations in women with familial or early-onset breast/ovarian cancer in the Czech Republic.

Human mutation - 1 Apr 2004

Foretova Lenka, Machackova Eva, Navratilova Marie, Pavlu Hana, Hruba Marcela, Lukesova Miroslava, Valik Dalibor

Abstract excerpt

Germline mutations in BRCA1 and BRCA2 account for majority of hereditary breast and ovarian cancer. The complete coding sequence analysis of both genes was carried out in 197 breast/ovarian cancer patients from high-risk families and 53 patients with sporadic breast/ovarian cancer. In summary, 59 mutations (16 different) in BRCA1 and 29 mutations (17 different) in BRCA2 were identified in unrelated breast and/or...

Topics

Adult
Age of Onset
Breast Neoplasms
Czech Republic
DNA Mutational Analysis
Female
Genes, BRCA1
Genes, BRCA2
Germ-Line Mutation
Humans
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Ovarian Neoplasms

Source

Identifiers

PMID: 15024741
DOI: 10.1002/humu.9226

Genes

BRCA1
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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