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Article

Epidermal growth factor receptor dependence in human tumors: more than just expression?

The oncologist - 1 Jan 2002

Arteaga Carlos L

Abstract excerpt

The epidermal growth factor receptor (EGFR) is a rational target for antitumor strategies. EGFR signaling causes increased proliferation, decreased apoptosis, and enhanced tumor cell motility and neo-angiogenesis. The EGFR is expressed or highly expressed in a variety of human tumors of epithelial origin. ZD1839 (Iressa) is an orally active, selective EGFR tyrosine kinase inhibitor, which blocks signal...

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Identifiers

PMID: 12202786
DOI: 10.1634/theoncologist.7-suppl_4-31

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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